Not now - I'd like more time to decide. Renew my subscription. Davis's Drug Guide. Tags Type your tag names separated by a space and hit enter. Citation Vallerand, April Hazard. Davis Company, Davis Company; Accessed November 12, Vallerand, A. In Davis's Drug Guide 16th edition. Davis Company. Carvedilol [Internet]. In: Davis's Drug Guide.
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Remember Me. Forgot your username or password? Purchase a subscription. The drug is rapidly absorbed and undergoes extensive first-pass metabolism in the liver. It reaches a peak concentration 1 to 2 hours postdose and has an elimination half-life of about 4 to 7 hours. Absorption is delayed by food. The drug is highly lipophilic and is highly protein bound.
The drug is metabolised by the liver, with some metabolites having biological activity. The pharmacokinetic profile is not altered in the elderly or in patients with renal disease. However, bioavailability of the oral medication is greatly increased in patients with liver disease.
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